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Related Experiment Video

Updated: May 28, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
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A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

Reducing Sedentary Time After Knee Replacement Using a Multicomponent mHealth Intervention: Randomized Controlled

Christine A Pellegrini1, Clare L Kennerley1, Sara Wilcox1,2

  • 1Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.

JMIR Mhealth and Uhealth
|May 26, 2026
PubMed
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This summary is machine-generated.

Reducing sedentary time after total knee replacement (TKR) is challenging. A mobile health intervention showed no significant overall reduction in sitting time but increased sit-to-stand transitions and moderate-to-vigorous physical activity with app use.

Area of Science:

  • Orthopedics
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Total knee replacement (TKR) is common for end-stage knee osteoarthritis.
  • Patients often don't increase physical activity post-TKR, despite pain reduction and mobility improvements.
  • Reducing sedentary behavior may be a feasible first step, but interventions are unstudied in TKR patients.

Purpose of the Study:

  • To assess the feasibility and effects of a 2-month mobile health intervention (NEAT!2) targeting sedentary time reduction in adults post-TKR.
  • To evaluate the intervention's impact on sedentary time, physical activity, function, and pain.

Main Methods:

  • 83 adults within 1 year of TKR were randomized to the NEAT!2 intervention or a control group.
  • NEAT!2 used a smartphone app to interrupt prolonged sitting and included 5 coaching calls.
Keywords:
arthroplastymHealthmobile healthphysical activitysedentary behavior

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Last Updated: May 28, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
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  • Outcomes were measured at 2 and 5 months using linear mixed-effects models.

    • Main Results:

    • High retention rates (95-96%) were observed in both groups.
    • The NEAT!2 group showed a significant increase in sit-to-stand transitions compared to controls at 5 months (P=.04).
    • No significant effects on overall sedentary time were found, but increased app use correlated with higher moderate-to-vigorous physical activity.

    Conclusions:

    • Reducing sitting time in adults post-TKR presents significant challenges.
    • Future research should explore broader behavior change strategies, including environmental and social factors.
    • Interventions implemented within the first year after TKR require further investigation.