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Related Experiment Video

Updated: May 28, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Development of a Digital Multimodal Pain Intervention (CHRONIC): Protocol for a Randomized Controlled Trial Study.

Gentian Bunjaku1, Lena Fellbaum2, Aaron Laufhütte2

  • 1Department of Psychosomatic Medicine and Psychotherapy, Medical School Hannover, Carl-Neuberg-Str. 1, Hannover, 30625, Germany, 49 511 532 6347.

JMIR Research Protocols
|May 26, 2026
PubMed
Summary

This randomized controlled trial evaluates CHRONIC, a digital multimodal program for chronic pain. It integrates Acceptance and Commitment Therapy, CBT, mindfulness, and physiotherapy to improve quality of life.

Keywords:
DiGAacceptance and commitment therapychronic paincognitive behavioral therapydigital health applicationmindfulnessself-help programtelemedicine

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Last Updated: May 28, 2026

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Area of Science:

  • Digital health interventions
  • Chronic pain management
  • Multimodal therapy

Background:

  • Chronic pain affects 12 million in Germany, impairing quality of life.
  • Multimodal treatment is gold standard but faces access barriers like long waiting times.
  • Digital health offers scalable, low-threshold solutions for chronic pain management.

Purpose of the Study:

  • Evaluate the effectiveness of the CHRONIC web-based program for chronic pain.
  • Assess CHRONIC's impact on pain intensity, pain-related interference, and quality of life.
  • Investigate CHRONIC as a scalable, low-threshold digital intervention.

Main Methods:

  • 12-week, 3-arm randomized controlled trial (RCT) with 200 participants.
  • Intervention groups receive individualized or standardized feedback; control is waitlist.
  • Weekly modules include psychotherapy, ACT/CBT exercises, mindfulness, and physiotherapy.

Main Results:

  • Recruitment ongoing; 18 participants enrolled as of January 2026.
  • Primary endpoint data collection expected by January 2027.
  • Primary analyses and dissemination planned for 2027.

Conclusions:

  • The study protocol outlines an RCT for the digital CHRONIC program.
  • CHRONIC integrates psychotherapeutic, physiotherapeutic, and mindfulness strategies.
  • Findings aim to inform digital health developments and biopsychosocial care models.