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Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management.
Zhiqi Li1,2, Zijie Li1,2, Yongmei Chen1
1Department of Clinical Laboratory, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital, Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou, Guangdong 510150, P. R. China.
ACS Nano
|May 26, 2026
Summary
A new continuous multiplexed monitoring system simultaneously tracks pH, glucose, and uric acid for diabetic nephropathy (DN) patients. This innovative device offers improved accuracy and potential for daily health management in DN care.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Nephrology
Background:
- Diabetic nephropathy (DN) is a major public health concern.
- Current continuous glucose monitoring (CGM) lacks comprehensive insights for DN patients.
Purpose of the Study:
- To develop a continuous multiplexed monitoring (CMM) system for simultaneous detection of pH, glucose (Glu), and uric acid (UA).
- To address limitations in current monitoring for diabetic nephropathy management.
Main Methods:
- Developed a novel "W-C-W" electrode multiplexing strategy using polyaniline (PANI) nanofibers.
- Integrated pH, glucose, and uric acid sensors into a single CMM system.
- Validated system performance and biocompatibility in vitro and in vivo (SD rats).
Main Results:
- Achieved excellent sensing performance with high sensitivities for pH, Glu, and UA.
- Demonstrated effective pH self-calibration for Glu and UA sensors.
- Showed decreased detection error and high correlation with commercial devices during long-term monitoring in rats.
Conclusions:
- The CMM system offers a promising solution for simultaneous monitoring of key biomarkers in diabetic nephropathy.
- The "W-C-W" strategy enables efficient multiplexing and self-calibration.
- The system has significant potential for enhancing daily health management for DN patients.
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