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Related Concept Videos

Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...

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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Butyrate improves dextran sulfate sodium-induced enterotoxicity in broilers.

Xinjie Bai1, Ran Li2, Tao Quan2

  • 1College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China; College of Animal Science and Technology, Beijing Vocational College of Agriculture, Beijing 102442, China.

Molecular Immunology
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Butyrate supplementation helps broiler chickens by shifting immune cells (macrophages) to an anti-inflammatory state, reducing intestinal inflammation and improving gut health. This supports better poultry farming practices.

Keywords:
ButyrateDextran sulfate sodiumEnterotoxicityMacrophages

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Area of Science:

  • Poultry immunology
  • Gut health research
  • Immunometabolism

Background:

  • Intestinal inflammation is a major issue in poultry farming, linked to macrophage imbalance.
  • Macrophages are key targets for butyrate in maintaining gut immune balance.
  • This study investigates butyrate's role in regulating macrophages to combat broiler enteritis.

Purpose of the Study:

  • To explore butyrate's regulatory effects on macrophages in broiler chickens.
  • To understand how butyrate ameliorates intestinal inflammation and enteritis.
  • To identify mechanisms underlying butyrate's beneficial actions.

Main Methods:

  • Induction of intestinal inflammation in broilers using dextran sulfate sodium (DSS).
  • Assessment of intestinal integrity, oxidative stress, and apoptosis.
  • Analysis of macrophage polarization (M1 vs. M2) and signaling pathways (HDAC3/AMPK/PPARγ/Hippo/GLUT1).

Main Results:

  • DSS-treated broilers showed reduced body weight, compromised gut integrity, and increased inflammation.
  • DSS induced M0 macrophages to polarize towards the pro-inflammatory M1 phenotype.
  • Butyrate supplementation promoted M2 macrophage polarization, reduced inflammation, and restored gut barrier function via specific signaling pathways.

Conclusions:

  • Butyrate promotes M2 macrophage polarization by modulating cellular metabolism, effectively reducing intestinal inflammation.
  • This research highlights the importance of immunometabolism in intestinal diseases.
  • Identifies potential therapeutic targets for managing enteritis in broilers.