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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Definitions of Fast Progression in Glaucoma Literature.

Andrea Servillo1, Camilla Patelli2, Alessandro Ghirardi2

  • 1Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.

Ophthalmology. Glaucoma
|May 26, 2026
PubMed
Summary

Definitions for fast glaucoma progression vary widely across studies, impacting prevalence and risk factor analysis. Standardizing these definitions is crucial for consistent research and clinical interpretation in glaucoma management.

Keywords:
Fast ProgressionGlaucomaOCTRapid ProgressionVisual field

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Area of Science:

  • Ophthalmology
  • Clinical Research
  • Data Science

Background:

  • Fast glaucoma progression is typically defined by numerical cut-offs, but lacks standardized thresholds and consistent methodologies.
  • Multiple analytical approaches and parameters are employed to estimate progression rates, leading to potential heterogeneity.

Purpose of the Study:

  • To systematically review and quantify the heterogeneity in definitions of fast glaucoma progression within the scientific literature.
  • To analyze the criteria, analytical methods, and structural or functional parameters used across studies.

Main Methods:

  • A systematic review was conducted using MEDLINE and EMBASE (PROSPERO: CRD42024502764).
  • Studies assessing fast glaucomatous progression using visual field (VF) testing, optic disc photography, optical coherence tomography (OCT), confocal scanning laser tomography (CSLT), and OCT angiography (OCT-A) were included.
  • Two independent reviewers extracted definitions of fast progression from eligible studies, excluding childhood glaucoma.

Main Results:

  • 122 studies yielded 88 definitions of fast progression, featuring 66 unique criteria and 16 analytic methods.
  • The most common definition was a Mean Deviation (MD) rate of <-1.0 dB/year using ordinary least squares regression (OLSR).
  • Visual field testing was the predominant method (84.4%), followed by OCT (20.5%), with MD being the most frequent index (66.3%).

Conclusions:

  • Definitions of fast glaucoma progression are predominantly visual field-based but exhibit significant variation in indices, analytical models, and thresholds.
  • This heterogeneity may influence reported prevalence, risk factor associations, and the interpretation of study outcomes.
  • Further research is needed to clarify the impact of different definitions on classifying fast progressors in glaucoma.