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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Tuberculosis Infection: Diagnosis and Management
Ibrahim Abubakar1, Jeremiah Chakaya2, David Hui3
1Institute for Global Health, University College London, London WC1E 6BT, United Kingdom i.abubakar@ucl.ac.uk.
Cold Spring Harbor Perspectives in Medicine
|May 26, 2026
Summary
Managing tuberculosis (TB) infection is key to global TB elimination. This review covers TB infection
Area of Science:
- Infectious Diseases
- Public Health
- Epidemiology
Background:
- Tuberculosis (TB) infection is the primary reservoir for the global TB epidemic and a crucial target for elimination efforts.
- Contemporary understanding views TB infection not as static but as a dynamic spectrum with varying progression risks.
Purpose of the Study:
- To synthesize current evidence on the natural history, epidemiology, diagnosis, treatment, and management of TB infection.
- To examine advances and implementation gaps in TB preventive treatment strategies.
Main Methods:
- Comprehensive review of existing literature and World Health Organization (WHO)-recommended diagnostic tools.
- Analysis of interferon-γ release assays and antigen-specific skin tests, noting their limitations in predicting progression.
- Examination of short-course rifamycin-based preventive regimens and strategies for drug-resistant TB exposure.
Main Results:
- Current diagnostic tests have limitations in predicting individual progression risk.
- Significant implementation gaps persist in the TB infection prevention cascade.
- Advances in preventive treatment offer new opportunities for TB control.
Conclusions:
- Effective management of TB infection is central to achieving global TB elimination goals.
- Future strategies must integrate TB infection management, addressing priority populations and ethical considerations.
- Emerging research in biomarkers, vaccines, and digital innovations holds promise for improved TB control.
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