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Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals
Alfred Amambua-Ngwa1,2, Daniel E Neafsey3,4, Sarah K Volkman5,4,6
1Medical Research Council Unit, The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia (West Africa).
Abstract:
The practice of malaria parasite genomics has evolved due to changing technology, expanded capacity, shifting funding, and broader applications. What began as a descriptive, discovery-focused field has grown into a global system for routine surveillance that informs public health decisions. This shift is supported by wider access to sequencing and new, cost-effective targeted sequencing methods. These changes, however, introduce new needs for standardizing data formats, analysis pipelines, sharing practices, and approaches for translating genomic insights into action. This review examines the progressive decentralization and diversification of malaria genomic data generation, highlights emerging applications enabled by these trends, and outlines key development needs and growth opportunities for this maturing field.
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