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Published on: June 10, 2025
[Predictive factors for in-hospital death after acute coronary syndrome: Data from REACTIV registry 2019 to 2023]
Insights
Acute coronary syndromes (ACS) in Abidjan are linked to significant in-hospital death. Key risk factors include age, diabetes, and severe heart rhythm disorders, while percutaneous coronary intervention (PCI) offers protection.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Acute coronary syndromes (ACS) represent a growing clinical challenge in Abidjan.
- Understanding in-hospital mortality predictors is crucial for improving patient outcomes.
Purpose of the Study:
- To identify factors predicting in-hospital death among patients with ACS at the Abidjan Heart Institute.
- To analyze trends in ACS prevalence and mortality over a five-year period.
Main Methods:
- An observational prospective study was conducted from January 2019 to December 2023.
- Data from 661 ACS patients admitted to the Intensive Care Unit (ICU) were analyzed.
- Multivariate analysis identified significant risk and protective factors for in-hospital mortality.
Main Results:
- ACS prevalence was 20.0% among ICU admissions, affecting a median age of 57 years with male predominance.
- Major cardiovascular risk factors included hypertension (55.6%), active smoking (33.4%), and diabetes (25.7%).
- In-hospital mortality was 9.5%, with age, diabetes, Killip class ≥2, and severe ventricular rhythm disorders identified as risk factors. Percutaneous coronary intervention (PCI) was protective (RR 0.4).
Conclusions:
- ACS is associated with substantial in-hospital mortality in Abidjan, with identifiable risk factors.
- Percutaneous coronary intervention (PCI) demonstrates a significant protective effect against in-hospital death.
- Developing ACS management networks and enhancing technical facilities are recommended to improve long-term outcomes.
Aim:
To assess the predictive factors for in-hospital death after acute coronary syndromes (ACS) in Abidjan Heart Institute.
Patients And Methods:
Observational prospective study from January, 2019 to December, 2023 using data from REgistre des syndromes coronAriens aigus de CôTe d'IVoire (REACTIV). Patients aged 18 years old and over admitted to the Intensive Care Unit (ICU) of the Abidjan Heart Institute for ACS were included. We collected socio-demographic, clinical, paraclinical and outcomes data. Predictive factors for in-hospital death were identified by multivariate analysis.
Results:
Six hundred and sixty one (661) patients presented with ACS among the 3302 admitted to the ICU of the Abidjan Heart Institute, giving an overall prevalence of 20.0%. ACS occurred in relatively young patients, with a median age of 57 years [48-65] and a male predominance (sex ratio=2.86). Hypertension (55.6%), active smoking (33.4%) and diabetes (25.7%) were the most common cardiovascular risk factors. Median admission time was 24 [8-72]h. Overall in-hospital mortality was 9.5%, decreasing from 11.2% in 2019 to 5.0% in 2023. In multivariate analysis, age (RR 1.08; CI95% 1.05-1.12), diabetes (RR 1.9; CI95% 1.1-3.3), Killip class≥2 on admission (RR 3.5; CI95% 2.1-5.8) and severe ventricular rhythm disorder (RR 8.3; CI95% 3.3-20.4), were risk factors for in-hospital death. Percutaneous coronary intervention (PCI), performed in 56% of patients, was a protective factor (RR 0.4; CI95% 0.2-0.7).
Conclusion:
ACS, which is increasing our practice, is responsible for high mortality, with well-identified in-hospital death risk factors. PCI appeared to be a protective factor. The implementation of ACS management networks and improved technical facilities should help improve long-term outcomes.
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