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X-chromosome gene dosage shapes MASLD beyond sex hormones

Mohamad Jamalinia1, Giovanni Targher2, Amedeo Lonardo3

  • 1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Trends in Endocrinology and Metabolism: TEM
|May 26, 2026
PubMed

Keywords:
Klinefelter syndromeMASLDTurner syndromeX-chromosome dosagesex differences

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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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X and Y Chromosomes

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