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Patient-specific 3D-printed HDR surface brachytherapy for basal cell carcinoma in older patients: prospective
Piotr Sobolewski1,2, Mateusz Koper1, Michal Poltorak1
1The National Medical Institute of the Ministry of the Interior and Administration, Woloska 137, 02-507 Warsaw, Poland.
Background:
Basal cell carcinoma (BCC) is common in older adults, many of whom are poor surgical candidates, especially for curved and cosmetically sensitive facial sites. High-dose-rate (HDR) surface brachytherapy is effective, but standard flat applicators may fit poorly and increase dose heterogeneity. Patient-specific 3D-printed applicators could improve conformity, yet geriatric BCC data are limited.
Objective:
To assess the feasibility and 12-month outcomes of personalized 3D-printed HDR surface brachytherapy in geriatric patients with BCC.
Methods:
In this prospective single-arm study, 15 patients aged ≥65 years with histologically confirmed BCC (predominantly facial) who were unsuitable for surgery received HDR surface brachytherapy using custom 3D-printed applicators. Treatment delivered 51 Gy in 17 fractions with CT-based planning. Repeat CT imaging evaluated applicator fit/reproducibility and target coverage. Acute skin toxicity was graded by RTOG. At 12 months, response was assessed clinically and dermoscopically; cosmesis and quality of life (Dermatology Life Quality Index [DLQI]) were recorded.
Results:
All patients completed treatment. Positioning was highly reproducible (mean setup error <1 mm) with >90% target dose coverage. At 12 months, all lesions achieved complete remission, with no local recurrence on dermoscopy. Acute reactions were mostly mild (73% grade 1), with 13% grade 2 and 13% grade 3; no grade 4 toxicity or serious adverse events occurred. Cosmesis was favorable, and DLQI improved (mean, 10.5 pre-treatment vs 2.9 at 1 year; P < .01).
Conclusions:
Personalized 3D-printed HDR surface brachytherapy appears feasible and well tolerated in this small, single-center cohort of older patients with BCC, with favorable 1-year local control and quality-of-life improvement when surgery is contraindicated. However, the limited sample size and single-center design represent limitation, and the observed benefit should be regarded as suggestive rather than definitive.
