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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...

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Related Experiment Video

Updated: May 28, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Association between essential trace elements, dietary patterns, and biological aging.

Wenqing Wang1,2, Kaixuan Yang3, Jiayi Li1

  • 1Department of Public Health, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, 322000, China.

European Journal of Nutrition
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Essential trace elements (ETEs) and dietary patterns impact biological aging (BA). Selenium (Se) and high-protein/plant-based diets decelerate BA, while pickled foods may weaken protective effects. Se mediates diet-aging relationships.

Keywords:
Biological agingDietary patternsEssential trace elementMixtureOlder adults

Related Experiment Videos

Last Updated: May 28, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Area of Science:

  • Gerontology
  • Nutritional Science
  • Biochemistry

Background:

  • Biological aging (BA) is a more accurate aging metric than chronological age (CA).
  • Essential trace elements (ETEs) and dietary patterns influence health, but their combined effects on BA are understudied.

Purpose of the Study:

  • To investigate the interactive effects of ETEs and dietary patterns on biological aging indicators in older adults.
  • To identify specific ETEs and dietary patterns associated with decelerated biological aging.

Main Methods:

  • Analysis of 2627 older adults (≥65 years) using two BA indicators: KDM-advance and homeostasis dysregulation (HD).
  • Dietary patterns identified via factor analysis; ETEs measured using ICP-MS and ICP-OES.
  • Associations explored using multiple linear regression, Bayesian kernel machine regression (BKMR), and quantile g-computation.

Main Results:

  • A mixture of ETEs was associated with decelerated BA, with Selenium (Se) being the primary contributor.
  • Increased Se intake correlated with reduced KDM-advance and HD.
  • High-protein and plant-based diets were linked to decelerated KDM-advance, while pickled foods attenuated the protective effects of Chromium (Cr) on HD.
  • Se mediated 17.2% of the relationship between high-protein diets and KDM-advance.

Conclusions:

  • Mixed ETEs, particularly Se, are negatively associated with BA indicators (KDM-advance, HD).
  • Dietary patterns interact with ETEs; pickled foods weaken Cr's protective effect on HD.
  • Findings support improving dietary guidelines for ETEs to promote healthy aging.