Cardiac damage stages at follow-up and subsequent clinical outcomes in patients with severe aortic stenosis

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Published on: May 21, 2017

Yasuaki Takeji1,2, Tomohiko Taniguchi3, Takeshi Morimoto4

  • 1Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Cardiovascular Intervention and Therapeutics
|May 26, 2026
PubMed

Insights

Cardiac damage stages predict outcomes in severe aortic stenosis patients managed conservatively, but not those treated with aortic valve replacement (AVR). Echocardiography at 1 year is key for prognosis in non-AVR patients.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Clinical Outcomes

Background:

  • Data on cardiac damage impact at 1 year post-treatment for severe aortic stenosis (AS) using echocardiography are limited.
  • Severe AS requires careful prognostic stratification to guide management strategies.

Purpose of the Study:

  • To evaluate the prognostic value of cardiac damage stages assessed by echocardiography at 1 year in patients with severe AS.
  • To compare the impact of initial treatment strategies (aortic valve replacement vs. conservative management) on outcomes based on cardiac damage.

Main Methods:

  • Analysis of 1991 patients from the CURRENT AS Registry-2 with severe AS.
  • Follow-up echocardiography at 1 year post-initial strategy (aortic valve replacement [AVR] or conservative management).
  • Assessment of primary outcome: composite of all-cause death or hospitalization for heart failure.

Main Results:

  • In the initial AVR group, cardiac damage stages were not significantly associated with the primary outcome.
  • In the conservative management group, higher cardiac damage stages significantly increased the risk of the primary outcome.
  • A significant interaction (P=0.003) was found between initial treatment strategy and cardiac damage stage on the primary outcome.

Conclusions:

  • Cardiac damage stages assessed by 1-year echocardiography are valuable for prognostic stratification in severe AS patients managed conservatively.
  • This prognostic utility was not observed in patients who underwent initial aortic valve replacement.
  • Treatment strategy significantly modifies the prognostic impact of cardiac damage in severe AS.

Keywords:
Aortic valve stenosisHeart failureTranscatheter aortic valve replacement

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