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Updated: May 28, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Deep medullary vein thrombosis in neonates: a retrospective study
Seh Hyun Kim1,2, Camilo Jaimes3, Linda S de Vries4
1Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Objective:
Deep medullary vein thrombosis (DMVT) is increasingly recognized on neonatal brain MRI, but its predisposing factors and clinical characteristics remain poorly defined. This study aims to evaluate the clinical characteristics and associated imaging features of DMVT in neonates.
Study Design:
We performed a retrospective single-center study of infants admitted to the neonatal intensive-care unit who underwent brain MRI between 2015 and 2023.
Result:
Over the study period, 23 infants had medullary vein abnormalities on brain MRI; of them, 10 (five preterm and five term) were identified as DMVT. Among preterm infants, four (80%) had intraventricular hemorrhage (IVH). All term infants demonstrated extensive (bilateral) DMVT.
Conclusion:
Medullary vein abnormalities are not uncommon on neonatal brain MRI. In preterm infants, they are often associated with IVH, whereas term infants typically exhibit bilateral extensive DMVT. Larger studies are needed to further explore the pathogenesis and long-term outcomes.
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