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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Sex-Specific Epigenetic Patterns in Endocannabinoid System Genes Following High-Altitude Exposure: An Exploratory

Carlotta Marrangone1, Alessio Mosca1, Manuel Marzola2

  • 1Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University, 66100 Chieti, Italy.

Brain Sciences
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

High-altitude exposure alters DNA methylation of stress-related genes, with sex-specific patterns observed in trekkers. These epigenetic changes may indicate stress adaptation and psychological responses.

Keywords:
altitudeendocannabinoid systemepigeneticpsychological distresssex differences

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
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A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Area of Science:

  • Environmental epigenetics
  • Psychoneuroendocrinology
  • Human physiology

Background:

  • High-altitude exposure is a significant psychophysiological stressor.
  • The endocannabinoid system (ECS) is crucial for stress regulation.
  • Epigenetic modulation of the ECS under extreme environments is understudied.

Purpose of the Study:

  • Investigate DNA methylation and microRNA (miRNA) expression of CNR1 and FAAH genes.
  • Examine associations with mood and anxiety in high-altitude trekkers.
  • Explore sex-specific epigenetic responses to extreme environmental stress.

Main Methods:

  • Longitudinal study of 21 lowlanders trekking from 2860 m to 5050 m.
  • Collected saliva samples at baseline (T0) and high altitude (T1).
  • Quantified CNR1 and FAAH DNA methylation via pyrosequencing and profiled exosomal miRNAs.

Main Results:

  • Observed heterogeneous and sex-specific DNA methylation patterns.
  • Males showed increased CNR1 promoter methylation at high altitude; females showed stability.
  • Preliminary miRNA data suggested context-dependent stress regulation, with exploratory links to CNR1 methylation in males.

Conclusions:

  • CNR1 epigenetic regulation may serve as an indicator of stress adaptation.
  • Sex differences are critical in understanding resilience and vulnerability to extreme environments.
  • Further research in larger cohorts is needed to confirm findings and explore mechanisms.