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Comparative Prefrontal Multimodal Physiological Signatures Under Active- and Passive-Fatigue-Inducing Simulated

Feiyang Zhang1, Dequan Fang1, Shiji Yuan2

  • 1School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China.

Brain Sciences
|May 27, 2026
PubMed
Summary

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This summary is machine-generated.

This study reveals distinct physiological changes in the brain

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Human Factors Engineering

Background:

  • Mental fatigue in driving presents as active (demanding tasks) or passive (monotonous tasks).
  • Limited research compares physiological responses to different fatigue types and levels.
  • Understanding fatigue progression is crucial for driver safety.

Purpose of the Study:

  • To compare prefrontal physiological signatures across three fatigue levels (non-fatigue, moderate, severe).
  • To investigate distinct responses under active versus passive simulated driving conditions.
  • To characterize electrophysiological, hemodynamic, and autonomic changes during fatigue.

Main Methods:

  • Utilized a prefrontal EEG-fNIRS system to record physiological data during simulated driving.
Keywords:
electroencephalographyfunctional near-infrared spectroscopymental fatigueprefrontal physiological signaturespulse rate variabilitysimulated driving

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  • Induced active and passive fatigue in 11 participants.
  • Classified fatigue into non-fatigue, moderate, and severe states based on subjective and objective measures.
  • Main Results:

    • Active fatigue showed early EEG and hemodynamic changes (non-fatigue to moderate).
    • Passive fatigue exhibited prominent EEG changes from moderate to severe fatigue.
    • Pulse rate variability increased in both active and passive fatigue paradigms.

    Conclusions:

    • Simulated driving paradigms induce unique prefrontal physiological responses across fatigue levels.
    • Findings support graded fatigue assessment and multimodal fatigue monitoring for drivers.
    • Distinct patterns of electrophysiological, hemodynamic, and autonomic changes were observed.