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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Prevention02:59

Cancer Prevention

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Chronic Bowel Disorders: Introduction

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Updated: May 28, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.

Meghana Maddula1, Jordan E Cohen1, Dulitha Kumarasinghe2

  • 1Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.

Cancers
|May 27, 2026
PubMed
Summary

Rising early-onset colorectal cancer (EOCRC) is linked to lifestyle and metabolic factors. Family history also contributes to sporadic EOCRC, suggesting genetic and environmental interactions.

Keywords:
early-onset colorectal cancerrisk factorssporadic colorectal cancersystematic review

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Area of Science:

  • Oncology
  • Epidemiology
  • Genetics

Background:

  • The incidence of early-onset colorectal cancer (EOCRC) is increasing globally.
  • Risk factors for sporadic EOCRC, especially in those without hereditary syndromes, are not fully understood.

Purpose of the Study:

  • To synthesize current evidence on modifiable and non-modifiable risk factors for sporadic EOCRC (<50 years old).

Main Methods:

  • Systematic review of observational studies published in English.
  • Searched PubMed and EMBASE databases from inception to March 2025.
  • Focused on consistency of associations due to varied effect measures across studies.

Main Results:

  • Identified 34 studies from 2575 initial papers.
  • Key risk factors include male sex, Caucasian ethnicity, and increasing age.
  • Obesity, metabolic syndrome, diabetes, Western diet, and sedentary behaviors are associated with higher EOCRC risk.
  • Moderate-to-vigorous exercise and higher vitamin D levels appear protective.
  • Family history of cancer is a significant risk factor for putatively sporadic EOCRC.

Conclusions:

  • Lifestyle (diet, sedentary behavior) and metabolic factors (obesity, diabetes) are linked to sporadic EOCRC.
  • Family history suggests influences beyond known hereditary syndromes, involving gene-environment interactions.
  • Future research should integrate genomic profiling for better risk stratification.