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Related Experiment Video

Updated: May 28, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Circulating Tumor Cells in Soft Tissue Sarcoma: Current Evidence and Clinical Implications.

Carolina Mendez-Guerra1, Jose Chacon2, Irvin E Altamirano3

  • 1Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15067, Peru.

Cancers
|May 27, 2026
PubMed
Summary

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Long-term Oncologic Outcomes After Unplanned Soft Tissue Sarcoma Surgery: Implications for Surveillance Strategies.

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Cancers·2025

Circulating tumor cells (CTCs) offer a promising liquid biopsy approach for soft tissue sarcoma (STS) patients. Research is exploring CTCs for early detection, treatment response monitoring, and prognosis in this rare cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Soft tissue sarcomas (STS) are rare, heterogeneous cancers with significant metastatic potential.
  • Early detection of metastasis is crucial for STS patient management.
  • Conventional imaging has limitations in detecting metastatic sites and tumor biology.

Purpose of the Study:

  • To review the biomolecular mechanisms of circulating tumor cells (CTCs) in STS.
  • To discuss current and emerging CTC detection methodologies for STS.
  • To explore the clinical implications of CTCs in STS treatment and prognosis.

Main Methods:

  • Narrative review of existing literature on CTCs in STS.
  • Analysis of biomolecular mechanisms including phenotypic plasticity, anoikis resistance, and stem cell-like phenotypes.
Keywords:
circulating tumor cellsliquid biopsyprecision oncologysoft tissue sarcoma

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
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Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
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Related Experiment Videos

Last Updated: May 28, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

  • Evaluation of current and novel CTC detection techniques.

    • Main Results:

    • CTCs offer a minimally invasive method for characterizing STS tumor biology and identifying prognostic biomarkers.
    • Phenotypic plasticity, anoikis resistance, and stem cell-like properties are key mechanisms for CTCs in STS.
    • Standardized CTC detection protocols are lacking, hindering clinical application in STS.

    Conclusions:

    • CTCs hold significant potential as prognostic biomarkers and for monitoring treatment response in STS.
    • Further research and standardized methods are needed to fully realize the clinical utility of CTCs in STS.
    • Subtype-specific CTC detection strategies are crucial for personalized STS management.