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OncoSolidDB: An Oncology-Focused Curated Database of Ligand-Target Interactions for Precision Medicine Across Major

Oussema Khamessi1,2, Rihab Mahjoub1,2, Ghada Mahjoub1,2

  • 1Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS-LAB) (LR16IPT09), Institut Pasteur de Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, Tunis 1002, Tunisia.

Cancers
|May 27, 2026
PubMed

Insights

OncoSolidDB is a new bioinformatics database consolidating ligand data for solid tumors. It aids researchers in drug discovery and developing targeted cancer therapies.

Area of Science:

  • Bioinformatics
  • Oncology
  • Drug Discovery

Background:

  • Targeted therapies in oncology rely on ligand-receptor interactions (LRI).
  • Data on cancer-associated ligands are fragmented across various sources.
  • Limited accessibility hinders research and clinical application of LRI data.

Purpose of the Study:

  • To develop OncoSolidDB, the first curated bioinformatics database for ligands targeting solid tumors.
  • To centralize and harmonize fragmented ligand data for oncology research.
  • To provide a comprehensive resource for advancing targeted cancer therapy development.

Main Methods:

  • Integrated data from ChEMBL, DrugBank, and Anti-Cancer Fund.
  • Consolidated structural, chemical, pharmacological, and clinical annotations.
  • Standardized identifiers and downloadable data formats (SMILES, PDB).

Main Results:

  • OncoSolidDB contains 243 ligands across 15 solid tumor types.
  • Includes data from 1953-2025, enabling trend analysis.
  • Web interface allows searching by cancer type, supporting various bioinformatics analyses.

Conclusions:

  • OncoSolidDB provides a unified platform for oncology-specific ligand data.
  • Facilitates drug discovery, repurposing, and rational design of targeted therapies.
  • A valuable resource for advancing solid tumor treatment strategies.
Keywords:
SMILESbioinformaticscancer databaseligand–receptor interactionsoncology drug databasesolid tumor ligands

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