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LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

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Microbial Dysbiosis in Photodermatoses: Formation, Pathogenesis and Intervention Strategies.

Lanhai Zhong¹, Tian Wang¹, Lu Tang¹

¹Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Current Issues in Molecular Biology

|May 27, 2026

Summary

Skin microbiome dysbiosis, marked by increased Staphylococcus aureus and reduced diversity, is linked to photodermatoses. Ultraviolet radiation (UVR) and immune factors worsen this imbalance, suggesting the skin microbiome as a therapeutic target.

Keywords:

Staphylococcus aureus photodermatoses skin microbiome tissue-resident memory T cells ultraviolet radiation

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Area of Science:

Dermatology
Microbiome Research
Immunology

Background:

Photodermatoses are associated with skin microbiome dysbiosis.
This dysbiosis includes increased Staphylococcus aureus colonization and reduced microbial diversity.
Ultraviolet radiation (UVR) and immune dysregulation are implicated in exacerbating these alterations.

Purpose of the Study:

To review the link between UVR, skin microbiome alterations, and cutaneous immune responses.
To outline a conceptual framework for understanding these interactions.
To identify potential therapeutic strategies targeting the skin microbiome.

Main Methods:

Literature review integrating findings from microbial ecology, molecular biology, and host immunology.
Analysis of mechanisms linking UVR exposure, microbiome changes, and inflammation.
Synthesis of current evidence on photodermatoses and skin microbiota.

Main Results:

UVR and atypical antimicrobial peptides may select for dysbiotic skin microbes.
Cytokine dysregulation and reduced commensals amplify dysbiosis.
Dysbiotic microbes activate immune responses, contributing to inflammation.

Conclusions:

The skin microbiome is a potential target for early intervention in photodermatoses.
Therapeutic strategies may include antibiotics, phototherapy, bleach baths, phage therapy, and microbiota-based therapies.
Further research is needed to address limitations and evidence gaps.