Related Experiment Video
Updated: May 28, 2026
09:50
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Enzymatic Modification of Flavonoids: Implications for Bioavailability, Bioactivity, and Therapeutic Potential Based
Marília Crivelari da Cunha1, Mariana Crivelari da Cunha2, Yasmin Bedani Scavone Ferrari1
1Health Sciences Postgraduate Program, Universidade São Francisco (USF), Bragança Paulista 12916-900, SP, Brazil.
Antioxidants (Basel, Switzerland)
|May 27, 2026
Summary
Enzymatic modification enhances flavonoid properties like solubility and bioavailability, improving their therapeutic potential. Further clinical trials are needed to confirm these benefits in humans.
Area of Science:
- Biochemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Flavonoids possess significant biological and therapeutic relevance.
- Clinical use is hindered by poor pharmacokinetics (solubility, bioavailability, metabolism).
- Enzymatic modification offers a sustainable approach to alter flavonoid structures.
Purpose of the Study:
- To systematically review enzymatic modification of flavonoids.
- To assess impacts on physicochemical properties, bioavailability, and biological activity.
- To evaluate therapeutic potential based on recent literature.
Main Methods:
- Systematic review following PRISMA 2020 guidelines (2015-2025).
- Literature search across PubMed, Scopus, Web of Science, with citation and bioinformatics analysis.
- Inclusion of in vitro, in vivo, and clinical study evidence.
Main Results:
- Enzymatic modifications (glycosylation, acylation, etc.) improve flavonoid stability and absorption.
- Enhanced biological activity observed across various experimental models.
- Significant improvements in physicochemical and pharmacokinetic properties demonstrated.
Conclusions:
- Enzymatic modification is a promising strategy to enhance flavonoid efficacy.
- Current evidence primarily from preclinical studies; limited clinical data available.
- Well-designed human clinical trials are essential to validate therapeutic applications.
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