A Retrospective Study on Correlations Between EEG Signals (N20, Spectral Entropy, and Alpha Variability) and...

Aim: To observe the correlations between electroencephalography (EEG) signals and clinical outcomes in patients with traumatic brain injury (TBI). Methods: A total of 174 patients diagnosed with TBI at Xiangya Hospital during January 2017 and June 2024 were included in this study. Quantitative EEG parameters, including spectral entropy (SE), alpha variability (RAV), and relative spectral energy (RBP), along with somatosensory evoked potential (SSEP) recordings (N20 amplitude) were assessed within 7-14 days after the disease onset. Patients were divided into a good-prognosis group and a poor-prognosis group based on the Glasgow Outcome Scale (GOS) scores at six months after discharge. Results: Significant correlations were found between the initial Synek EEG grading and 6-month GOS score (ρ = -0.709, p < 0.001). Compared with patients in the poor-prognosis group, significantly higher N20 amplitudes (p < 0.001), higher SE (p = 0.049), higher RAV (p = 0.009), and lower relative beta energy (p < 0.05) were found in TBI patients with good prognosis. Among these parameters, N20 amplitude demonstrated the best predictive performance. The N20 amplitude threshold of >1.975 μV predicted a good outcome with a sensitivity of 93.3% and a specificity of 94.1%. Conclusions: These findings may provide a reliable and sensitivity method to evaluate and predict the prognosis of TBI patients, which has important clinical management significance.