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Updated: May 28, 2026

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System

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Published on: April 30, 2018

DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models.

Gan-Qiang Lai¹, Yan Yan¹, Mohini Sengupta²

¹Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

|May 27, 2026

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Zebrafish models offer unique insights into DNA methylation, a key epigenetic process crucial for development and disease. Studying DNA methylation dynamics in zebrafish aids in understanding human diseases and discovering new therapies.

Area of Science:

Epigenetics and Developmental Biology
Comparative Genomics
Disease Modeling

Background:

DNA methylation is vital for gene expression, genome stability, and cell identity during vertebrate development.
Aberrant DNA methylation is linked to human diseases like cancer and developmental disorders.
Understanding DNA methylation dynamics is critical for disease mechanism elucidation and therapeutic development.

Purpose of the Study:

To review the current understanding of the zebrafish methylome and its regulatory enzymes.
To discuss the role of DNA methylation in early development, organogenesis, and cell fate decisions using zebrafish.
To highlight insights from zebrafish disease models and emerging technologies for epigenetic research.

Main Methods:

Review of existing literature on zebrafish DNA methylation.

Keywords:

DNA methylation DNA methyltransferase disease model drug discovery zebrafish

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Last Updated: May 28, 2026

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System

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Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos

Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos

Published on: August 18, 2022

Analysis of conserved epigenetic machinery (DNMTs, TETs) between zebrafish and humans.

Examination of zebrafish as a model for studying in vivo epigenetic processes.

Main Results:

Zebrafish possess conserved DNA methylation machinery (DNMTs, TETs) and exhibit dynamic methylation patterns crucial for development.
Zebrafish models provide valuable insights into how DNA methylation influences embryonic development and organogenesis.
Studies in zebrafish have illuminated disease mechanisms related to epigenetic dysregulation.

Conclusions:

Zebrafish are a powerful vertebrate model for studying DNA methylation dynamics in vivo due to their developmental advantages.
Research in zebrafish contributes significantly to understanding the link between developmental epigenetics and human disease.
Emerging technologies in zebrafish research promise more precise interrogation of epigenetic regulation for therapeutic discovery.