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A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
Circadian Activity Disruption in Cardiac Remodeling Patients Underlies Autonomic Dysfunction in Heart Failure
Natalia Buitrago-Ricaurte1, Andre J Riveros2,3, Rafael González Niño4
1Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia.
Biomedicines
|May 27, 2026
Summary
Cardiac remodeling (CR) alters autonomic cardiac dynamics, reducing heart rate variability (HRV) oscillations and shifting circadian rhythms. This study reveals significant changes in HRV and nonlinear dynamics in CR patients over a 24-hour period.
Area of Science:
- Cardiology
- Physiology
- Chronobiology
Background:
- Heart failure (HF) is a complex syndrome with diverse clinical presentations.
- Cardiac remodeling (CR) helps explain HF variability but its impact on autonomic cardiac dynamics across circadian cycles is unclear.
Purpose of the Study:
- To investigate the influence of cardiac remodeling on autonomic cardiac dynamics throughout the circadian cycle.
- To analyze heart rate variability (HRV) and nonlinear dynamics in patients with CR.
Main Methods:
- Analyzed 24-hour ECG recordings from 86 CR patients and 86 controls.
- Estimated HRV parameters using Blackman-Harris windows and assessed autonomic influences via time, frequency, and nonlinear methods.
- Derived circadian parameters (MESOR, amplitude, acrophase) using Cosinor modeling, controlling for covariates.
Main Results:
- CR patients showed reduced HRV oscillatory activity, lower MESOR and amplitude, and an advanced-phase phenotype.
- Nonlinear dynamics revealed decreased complexity and entropy in CR patients.
- Significant differences in circadian HRV parameters and nonlinear dynamics were observed in CR.
Conclusions:
- Cardiac remodeling is associated with altered circadian rhythmicity of cardiac electrical activity.
- Changes in circadian HRV parameters and nonlinear dynamics are key indicators of CR's impact on autonomic control.
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