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Procalcitonin Elevation in Intoxication- and Immobilization-Related Non-Traumatic Rhabdomyolysis: Association with
Linas Zdanavičius1, Gabija Laubner Sakalauskienė2, Viktorija Antonova Šiaudvytė3
1Clinic of Emergency Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.
Biomedicines
|May 27, 2026
Summary
Procalcitonin (PCT) elevation in non-traumatic rhabdomyolysis correlates with muscle injury and kidney dysfunction, not infection. Further studies are needed to confirm these findings in diverse patient groups.
Area of Science:
- Biochemistry
- Nephrology
- Critical Care Medicine
Background:
- Procalcitonin (PCT) is a biomarker for bacterial infection but can elevate in non-infectious inflammation.
- Non-traumatic rhabdomyolysis involves muscle breakdown and can lead to complications like kidney injury.
- The role of PCT in non-traumatic rhabdomyolysis requires further investigation.
Purpose of the Study:
- To investigate the association between PCT levels and muscle injury severity.
- To examine the relationship of PCT with renal dysfunction in non-traumatic rhabdomyolysis.
- To determine if infection status independently predicts PCT levels in this condition.
Main Methods:
- Prospective enrollment of 39 adult patients with non-traumatic rhabdomyolysis.
- Collected longitudinal data on creatine kinase (CK), myoglobin, PCT, C-reactive protein (CRP), creatinine, and urea.
- Utilized Spearman correlation, linear regression, and linear mixed-effects models for analysis.
Main Results:
- Admission PCT positively correlated with creatinine, CK, urea, and CRP.
- Creatinine and CK independently predicted admission PCT levels, while infection status did not.
- Longitudinal analysis showed CK remained associated with PCT over time, independent of infection status.
Conclusions:
- PCT elevation in non-traumatic rhabdomyolysis is linked to muscle injury and renal dysfunction.
- Infection was not an independent predictor of PCT in this cohort.
- Findings require confirmation in larger, more diverse rhabdomyolysis populations due to the exploratory nature and sample size.
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