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Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
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Differences in Intestinal Flora and Its Related Metabolite Between Healthy and Diarrheal Piglets: Strategies for
Ling Zhang1, Beiying Yang1, Baosheng Liu1
1College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Animals : an Open Access Journal From MDPI
|May 27, 2026
Summary
Piglet diarrhea is linked to gut flora imbalance. Healthy piglets have more Lactobacillus and Enterococcus, which correlate with beneficial metabolites that may prevent diarrhea.
Area of Science:
- Veterinary Microbiology
- Animal Science
- Metabolomics
Background:
- Piglet diarrhea significantly impacts pig farming.
- Intestinal flora dysbiosis is a key cause of piglet diarrhea.
- Understanding piglet gut microbiota is vital for diarrhea prevention.
Purpose of the Study:
- To investigate differences in intestinal flora and metabolites between healthy and diarrheal piglets.
- To identify key microbial players and metabolites associated with piglet gut health.
- To explore the functional role of specific bacteria and metabolites in preventing piglet diarrhea.
Main Methods:
- High-throughput sequencing for microbiota analysis.
- Untargeted liquid chromatography-mass spectrometry (LC-MS) for metabolomics.
- Correlation analysis between microbiota composition and metabolite profiles.
Main Results:
- Healthy piglets showed higher abundance of Lactobacillus and Enterococcus.
- Amino acids, sesquiterpenoids, and triterpenoids were significantly higher in healthy piglets.
- These metabolites positively correlated with Lactobacillus and Enterococcus abundance.
Conclusions:
- Lactobacillus and Enterococcus are dominant in healthy piglets.
- Specific metabolites are associated with beneficial gut bacteria.
- These bacteria and their metabolites may play a role in maintaining piglet intestinal health and preventing diarrhea.
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