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Related Experiment Video

Updated: May 28, 2026

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

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Published on: March 25, 2016

Intersecting Roles of Estrogens and Neutrophils in Modulating Innate Immunity in Cancer.

Mary Wines-Samuelson¹, Thomas R Henson^2,3, Raegan J Myers^2,3

¹Wegmans School of Pharmacy, St. John Fisher University, Rochester, NY 14618, USA.

|May 27, 2026

Summary

This summary is machine-generated.

Steroid hormones impact cancer metastasis by influencing neutrophils and neutrophil extracellular traps (NETs). Understanding these innate immune interactions is crucial for developing novel cancer therapies.

Keywords:

NETosis NETs cancer estrogen innate immunity neutrophil steroid hormone

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Area of Science:

Oncology
Immunology
Endocrinology

Background:

Steroid-sensitive cancers often metastasize, and while direct hormone effects on tumors are known, indirect effects via the innate immune system are less understood.
Current cancer therapies focus on adaptive immunity, with limited investigation into the innate immune system's role in cancer progression.
Neutrophils, key innate immune cells, are increasingly recognized for their complex roles in cancer, influenced by steroid hormones.

Purpose of the Study:

To explore the indirect effects of steroid hormones on cancer metastasis through the innate immune system.
To highlight the significance of neutrophils and neutrophil extracellular traps (NETs) in the context of steroid hormone influence on cancer.
To discuss how interactions between steroid hormones and neutrophils modulate tumor growth and invasion.

Main Methods:

Review of recent studies focusing on animal models of cancer.
Analysis of neutrophil responses to tumorigenic conditions with and without steroid hormones.
Examination of the relationship between steroid hormones, neutrophils, and NETs.

Main Results:

Steroid hormones significantly influence neutrophil behavior and function in the tumor microenvironment.
Neutrophil extracellular traps (NETs) play a role in mediating the effects of steroid hormones on cancer cell invasion and metastasis.
Interactions between steroid hormones and neutrophils can either promote or inhibit tumor progression depending on the context.

Conclusions:

The innate immune system, particularly neutrophils and NETs, is a critical mediator of steroid hormone effects in cancer.
Targeting the interplay between steroid hormones and innate immunity, alongside adaptive immunity, may offer improved therapeutic strategies for steroid-sensitive cancers.
Further research into the complex mechanisms of innate immunity in cancer is warranted to enhance treatment outcomes.