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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

Updated: May 28, 2026

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
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Published on: September 26, 2014

PEG-Dependent Tunable Degradation and Curcumin Release from Curcumin-Based Biomedical Polyurethanes.

Man Wang1, Hongying Liu2, Wei Zhao1

  • 1High & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, China.

Biomolecules
|May 27, 2026
PubMed
Summary

This study developed novel curcumin-based polyurethanes (Cur-PU) to improve curcumin

Keywords:
PEG-dependentbiocompatibilitybiodegradabilitycurcumin deliverypolyurethane

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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

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Published on: September 6, 2012

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Curcumin possesses valuable antioxidant and anti-inflammatory properties.
  • Poor water solubility and oxidative instability limit curcumin's biomedical applications.
  • Biomedical polyurethanes offer a potential delivery matrix for curcumin.

Purpose of the Study:

  • To synthesize and characterize novel curcumin-based polyurethanes (Cur-PU).
  • To investigate the effect of polyethylene glycol (PEG) content on Cur-PU properties.
  • To evaluate the degradation and curcumin release kinetics of Cur-PU.

Main Methods:

  • Synthesis of Cur-PU using HO-PCL-OH, HO-PEG-OH, and curcumin.
  • Characterization of Cur-PU thermal properties (Tm, Tc, Hc) and crystallinity.
  • Assessment of hydrophilicity, swelling, degradation, and curcumin release rates.
  • Biocompatibility testing including antioxidant and antibacterial activity assays.

Main Results:

  • Increasing PEG content decreased Cur-PU crystallinity and crystallization rate.
  • Higher PEG content enhanced hydrophilicity, swelling, and degradation rates.
  • Curcumin release rate was precisely controlled by adjusting PEG content.
  • Cur-PU demonstrated excellent antioxidant and antibacterial activities.

Conclusions:

  • Cur-PU offers a tunable platform for controlled curcumin delivery.
  • The developed Cur-PU materials show significant promise for biomedical applications.
  • PEG content is a critical factor in optimizing Cur-PU performance for drug delivery.