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Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases
Yiyang Cui1, Yuxuan Wen1, Xinling Wang2
1The Queen Mary School, Jiangxi Medical College, Nanchang University, 999 Xuefu Road, Nanchang 330031, China.
Insights
Tripartite motif (TRIM) proteins are involved in cardiovascular diseases. Understanding TRIM proteins offers new therapeutic strategies for heart conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) cause high mortality and societal burden.
- Traditional CVD drugs like statins have limitations, necessitating novel therapeutic targets.
- The tripartite motif (TRIM) protein family, known for E3 ubiquitin ligase activity, regulates diverse cellular processes.
Purpose of the Study:
- To review the structure and function of TRIM proteins.
- To elucidate the mechanisms by which TRIM proteins contribute to cardiovascular diseases.
- To highlight the potential of TRIM proteins as therapeutic targets for CVDs.
Main Methods:
- Literature review of existing research on TRIM proteins and cardiovascular diseases.
- Analysis of the role of TRIM proteins in various CVDs including cardiac hypertrophy, ischemia-reperfusion injury, heart failure, hypertension, and atherosclerosis.
- Synthesis of current understanding of TRIM protein involvement in CVD pathogenesis.
Main Results:
- TRIM proteins are implicated in the progression of multiple cardiovascular diseases.
- Specific TRIM proteins play critical roles in cardiac hypertrophy, ischemia-reperfusion injury, heart failure, hypertension, and atherosclerosis.
- The E3 ubiquitin ligase activity of TRIM proteins is central to their function in cardiovascular regulation.
Conclusions:
- TRIM proteins are significant players in cardiovascular disease development and progression.
- Targeting TRIM proteins presents a promising avenue for novel therapeutic strategies against cardiovascular diseases.
- Further research into TRIM protein mechanisms is crucial for developing effective CVD treatments.
Abstract:
Cardiovascular diseases have high mortality rates and present a high burden on society and the global healthcare system. A large quantity of drugs have been developed, such as aspirin, ACE inhibitors, beta-blockers, and statins. Although these traditional drugs have decreased the morbidity and mortality of cardiovascular diseases, they still have multiple limitations. Due to their shortcomings, researchers have continued to search for novel targets for drug treatment. The tripartite motif (TRIM) protein family is a superfamily with E3 ubiquitin ligase activity and involves diversified processes including proliferation, development, signal transduction, and immune regulation. The latest research has shown that TRIM proteins participate in the progression of cardiovascular diseases, such as cardiac hypertrophy, cardiac ischemia-reperfusion injury, heart failure, hypertension, atherosclerosis, and so on. In this review, we summarize the structure and function of TRIM proteins, as well as the mechanisms of their involvement in various cardiovascular diseases, aiming to raise awareness of the importance of TRIM proteins in cardiovascular disease research and treatment. Advancing our understanding of mechanisms mediated by TRIM proteins may emphasize their contributions to cardiovascular diseases and provide the opportunity to develop novel and targeted therapeutic strategies to combat cardiovascular diseases.
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