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Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation-Unlocking Natural
Xinyan Wang1, Chenchen Yuan1, Rong Lu1
1Marine College, Shandong University, Weihai 264209, China.
Biomolecules
|May 27, 2026
Summary
Plant-derived nanovesicles (PDNVs) show promise in nanomedicine and skincare due to their biocompatibility. This review addresses challenges in PDNV extraction, purification, and modification to accelerate their clinical translation and industrialization.
Area of Science:
- Biotechnology
- Nanomedicine
- Plant Science
Background:
- Plant-derived nanovesicles (PDNVs) are natural nanocarriers with potential in medicine, skincare, and nutrition.
- PDNVs offer biocompatibility, low immunogenicity, and targeted delivery, but face challenges in clinical translation.
- Existing research on PDNVs lacks comprehensive reviews compared to mammalian extracellular vesicles (M-EVs).
Purpose of the Study:
- To comprehensively review the progress and challenges of PDNVs over the last 60 years.
- To identify shortcomings in PDNV purification, characterization, modification, and clinical translation.
- To explore innovative approaches like AI and interdisciplinary integration for PDNV advancement.
Main Methods:
- Systematic review of literature on PDNVs spanning 60 years.
- Analysis of PDNV purification processes, composition, characterization, and engineering modifications.
- Evaluation of functional mechanisms, clinical translation, and market regulation of PDNVs.
Main Results:
- Identified key bottlenecks in PDNVs including low extraction efficiency, complex purification, and immature engineering.
- Highlighted the need for standardized characterization and advanced modification techniques for PDNVs.
- Discussed the potential of AI and interdisciplinary approaches to overcome current limitations.
Conclusions:
- PDNVs possess significant potential but require overcoming substantial technical and regulatory hurdles for industrialization.
- Innovative strategies are crucial to bridge the gap between laboratory research and clinical application of PDNVs.
- This review provides a foundation for future research and development in naturally derived nanomedicines.
