Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structured Antenatal Counselling Improves Maternal Influenza and Pertussis Uptake: A Prospective Comparative Study in Greece.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Determinants of Maternal RSV Vaccination Uptake: A Narrative Review.

Vaccines·2026
Same author

Knowledge, attitudes, and practices of pediatricians in Crete, Greece, regarding RSV immunization: a cross-sectional study.

European journal of pediatrics·2026
Same author

Influenza-Associated Benign Acute Childhood Myositis During the 2024-2025 Season: A Retrospective Multicenter Study.

Children (Basel, Switzerland)·2025
Same author

SARS-CoV-2 Variants and Their Impact on Pediatric COVID-19: Clinical Manifestations and Hematological Profiles.

Diseases (Basel, Switzerland)·2025
Same author

Indicators of Glucose Metabolism in Children and Adolescents Characterized as Having "Metabolically Healthy" and "Metabolically Unhealthy" Obesity.

Children (Basel, Switzerland)·2025

Related Experiment Video

Updated: May 28, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Early-Onset Neonatal Sepsis: Clinical System Involvement and Maternal-Neonatal Risk Profiles in a Retrospective

Anna Damatopoulou1,2, Michail Matalliotakis1, Fani Ladomenou3

  • 1Department of Obstetrics and Gynecology, Venizeleio General Hospital of Heraklion, 71409 Heraklion, Greece.

Children (Basel, Switzerland)
|May 27, 2026
PubMed
Summary

Respiratory issues are most common in early-onset sepsis (EOS) in newborns. Prematurity and maternal factors increase the risk of severe disease, guiding better risk stratification for neonatal care.

Keywords:
clinical system involvementearly-onset neonatal sepsisrisk factors

More Related Videos

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Related Experiment Videos

Last Updated: May 28, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

  • Neonatology
  • Pediatric Infectious Diseases
  • Clinical Medicine

Background:

  • Neonatal sepsis is a significant cause of infant illness and death globally.
  • Diagnostic challenges and varied symptoms complicate early detection and treatment of neonatal sepsis.
  • Early-onset sepsis (EOS), occurring within 72 hours of birth, is heavily influenced by maternal and perinatal conditions.

Purpose of the Study:

  • To identify the primary clinical systems affected in preterm and term neonates with suspected or confirmed sepsis.
  • To determine maternal and neonatal risk factors linked to early disease severity, persistent sepsis, and adverse outcomes.

Main Methods:

  • A cohort of 297 neonates admitted before 72 hours of life was analyzed.
  • Daily clinical system involvement was documented.
  • Maternal and neonatal risk factors were assessed to predict sepsis severity, persistence, and mortality.

Main Results:

  • Respiratory involvement was the most frequent clinical manifestation on Day 1 (57.2%) and persisted through Day 3.
  • Lower gestational age and prolonged rupture of membranes (>18 hours) predicted sepsis at Day 1.
  • Factors like low birth weight, prematurity, older maternal age, and lack of intrapartum antibiotics were associated with advanced sepsis and persistent disease.

Conclusions:

  • Respiratory compromise is the predominant clinical feature in early-onset neonatal sepsis.
  • Prematurity, low birth weight, prolonged rupture of membranes, and maternal intrapartum infection are key risk factors for severe neonatal sepsis.
  • Understanding the clinical progression aids in risk stratification and may help reduce antibiotic overuse.