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Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: May 28, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Postnatal CMV Infection in Extremely Premature Newborns: A Single-Center Exploratory Study.

Rok Košiček¹, Vanja Erčulj^2,3, Lilijana Kornhauser Cerar⁴

¹Department of Anaesthesiology, Celje General Hospital, 3000 Celje, Slovenia.

Children (Basel, Switzerland)

|May 27, 2026

Summary

Postnatal cytomegalovirus (CMV) infection in extremely premature newborns is linked to more severe illness, including hepatosplenomegaly and lower blood cell counts. Preventing CMV infection is crucial for these vulnerable infants.

Keywords:

breast milk extremely premature newborns leukopenia postnatal CMV thrombocytopenia

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Area of Science:

Neonatalogy
Infectious Diseases
Perinatology

Background:

Postnatal cytomegalovirus (CMV) infection impact in extremely premature infants (<29 weeks gestational age) is not well understood.
This study investigates outcomes of postnatal CMV in a specific cohort of very premature newborns.

Purpose of the Study:

To determine the impact and outcomes of postnatal CMV infection.
To analyze clinical characteristics and treatment results in extremely premature newborns.

Main Methods:

Inclusion of 63 extremely premature newborns (<29 weeks GA) from December 2022 to December 2024.
CMV infection screening via PCR; congenital infection excluded. Postnatal infection confirmed with clinical suspicion and PCR.
Maternal CMV serostatus determined; clinical data and outcomes collected.

Main Results:

14 out of 63 newborns (22.2%) had confirmed postnatal CMV infection.
CMV infection associated with hepatosplenomegaly and decreased platelet/leukocyte counts.
No significant association found between postnatal CMV and other neonatal comorbidities.

Conclusions:

Postnatal CMV infection correlated with a more severe clinical course in extremely premature infants.
Multivariable analysis did not confirm a statistically significant association with prolonged hospital stay.
Findings underscore the importance of preventing postnatal CMV infection in this high-risk population.