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Is Intravenous Magnesium Sulfate Beneficial in Children with Acute Asthma Exacerbation and Acute Bronchiolitis? A
Yasin Selcuk Yardibi1, Begum Baris Cetinkaya1, Zeynep Tobcu1
1Department of Pediatrics, Faculty of Medicine, Bandırma Onyedi Eylül University, 10200 Bandırma, Türkiye.
Background/Objectives:
Asthma, one of the most common chronic diseases in childhood, and acute bronchiolitis, a leading cause of hospitalization in early childhood, remain significant contributors to morbidity and mortality.
Methods:
This retrospective cohort study evaluated the efficacy and safety of intravenous magnesium sulfate (IV MgSO4) as a secondary treatment in pediatric patients with acute asthma exacerbation unresponsive to first-line therapy and in patients with acute bronchiolitis unresponsive to supportive care. A total of 450 patients aged 6 months to 18 years, including 252 with acute asthma exacerbation and 198 with acute bronchiolitis, were included.
Results:
Significant improvements in peripheral capillary oxygen saturation were observed after IV MgSO4 administration in both groups (p < 0.001). In the acute asthma exacerbation group, IV MgSO4 also significantly reduced tachypnea compared to the acute bronchiolitis group (p < 0.001). No adverse effects related to IV MgSO4 were observed.
Conclusions:
These findings suggest that IV MgSO4 may be both beneficial and safe as an early secondary treatment in acute asthma exacerbations.
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