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Updated: May 28, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

The Complex Relationship Between HDL/LDL Cholesterol, Stroke and Cardiovascular Disease.

Mark Parker¹, Tanja Novaković¹, Milica Krga Rastović¹

¹ZEM Solutions, 11050 Belgrade, Serbia.

Healthcare (Basel, Switzerland)

|May 27, 2026

Summary

Maintaining a healthy HDL-C/LDL-C ratio and reducing LDL-C significantly improves cardiovascular survival and longevity. This study quantifies the lifetime benefits of lipid control for preventing atherosclerotic cardiovascular disease (ASCVD).

Keywords:

ASCVD HDL-C LDL-C big data analytics cardiovascular risk modelling multi-disease modelling myocardial infarction stroke

Related Experiment Videos

Last Updated: May 28, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

Cardiology
Public Health
Epidemiology

Background:

Atherosclerotic cardiovascular disease (ASCVD) is a leading global cause of mortality, with lipid abnormalities being central to its development.
The impact of combined lipid profiles, particularly the HDL-C/LDL-C ratio, on long-term population health outcomes requires further quantification.

Purpose of the Study:

To estimate the lifetime burden of cardiovascular outcomes associated with various lipid risk profiles.
To utilize a patient-level simulation framework for projecting individual health trajectories and quantifying ASCVD impact.

Main Methods:

Analysis of projected lifetime ASCVD events across four HDL-C/LDL-C risk strata (low to very high).
Utilized the National Health Model Database of Projected and Estimated Outcomes (NHM-DPEO), a digital twin of national healthcare systems.
Employed a patient-level simulation model projecting individual health trajectories over a lifetime horizon.

Main Results:

A strong, graded relationship was observed between lipid profiles and cardiovascular survival, with life expectancy declining by up to 17.2 years in the very-high-risk group (HDL-C/LDL-C < 0.25).
Participants with LDL-C > 5.0 mmol/L had a life expectancy 13.4 years shorter than those with LDL-C < 3.1 mmol/L.
The burden of ASCVD increased exponentially with worsening lipid ratios, with MI events rising significantly and onset occurring as early as age 20 in the highest-risk group.

Conclusions:

Lipid balance decisively influences cardiovascular survival, with sustained LDL-C reduction and favorable HDL-C/LDL-C ratios markedly extending life expectancy.
Early and continuous lipid control is crucial for ASCVD prevention, offering substantial survival benefits across all demographics.
The NHM framework provides valuable insights for targeted strategies to improve longevity and quality of life by quantifying lifetime effects of lipid management.