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Tricuspid Regurgitation: Pathophysiology, Risk Stratification, and Implications for Intervention
Mariagrazia Piscione1,2, Barbara Pala3,4, Dario Gaudio5
1Asl 2 Abruzzo, Santissima Annunziata Hospital, 66100 Chieti, Italy.
Journal of Clinical Medicine
|May 27, 2026
Summary
Tricuspid regurgitation (TR) drives right heart failure (HF) progression, creating a cycle of worsening right ventricular dysfunction and systemic congestion. A multiparametric risk assessment is crucial for effective management.
Area of Science:
- Cardiology
- Cardiovascular Medicine
- Pulmonology
Background:
- Right heart failure (HF) and tricuspid regurgitation (TR) share a complex, bidirectional relationship.
- Right ventricular (RV) dysfunction is central to the progression of both conditions.
Purpose of the Study:
- To review the pathophysiology of right HF and TR.
- To examine clinical implications and risk stratification strategies for TR and RHF.
Main Methods:
- Comprehensive literature review focusing on RV dysfunction, pulmonary vascular load, and VA coupling.
- Analysis of current risk stratification models, including disease-specific approaches.
Main Results:
- TR is both a cause and consequence of RHF, exacerbating RV volume overload and systemic dysfunction.
- TRISCORE offers a more comprehensive risk assessment by integrating clinical, biological, and echocardiographic data.
Conclusions:
- TR is a key determinant of RHF progression, not just a marker.
- A multiparametric approach is essential for optimal therapeutic strategies and clinical decision-making.
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