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Related Experiment Video

Updated: May 28, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Breast Cancer Surgery: Past, Present and Future-A Narrative Review.

Paolo Izzo1, Marcello Molle2, Pierfrancesco Di Cello3

  • 1"Pietro Valdoni" Department of Surgery, Policlinico "Umberto I", Sapienza University of Rome, 00161 Rome, Italy.

Journal of Clinical Medicine
|May 27, 2026
PubMed
Summary

Breast cancer surgery is becoming less invasive, focusing on personalized care. Advances allow for reduced breast and axillary surgery without compromising safety, driven by biology and systemic therapy response.

Keywords:
artificial intelligencebreast cancer surgeryintraoperative radiotherapymastectomyneoadjuvant systemic therapyoncoplastic surgeryrobotic mastectomysentinel lymph node biopsy

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Last Updated: May 28, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Area of Science:

  • Surgical Oncology
  • Breast Cancer Management

Background:

  • Breast cancer surgery has transitioned from radical to individualized approaches.
  • Current trends emphasize less invasive surgical strategies.

Purpose of the Study:

  • To review the evolution of breast cancer surgery towards de-escalation.
  • To synthesize evidence supporting reduced surgical interventions.
  • To examine emerging strategies for further surgical de-escalation.

Main Methods:

  • Narrative review of PubMed/MEDLINE literature.
  • Appraisal of major international guidelines.
  • Prioritization of randomized trials, prospective studies, and consensus statements.

Main Results:

  • Contemporary practice shows reduced breast and axillary surgery due to advances in tumor biology, neoadjuvant therapy, sentinel node biopsy, and oncoplastic techniques.
  • Emerging strategies include selective axillary surgery omission and targeted axillary dissection.
  • A shift towards response-adapted and biology-driven care is evident.

Conclusions:

  • The field is moving towards minimizing surgical burden while maintaining oncological safety.
  • Future progress depends on improved patient selection, imaging, and integration of systemic therapy response.
  • Technological innovations may influence but have limited roles in true de-escalation.