Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoinflammatory syndromes in chronic urticaria are rare but clinically distinct: A retrospective cohort study.

JAAD international·2026
Same author

BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma.

Cell reports. Medicine·2026
Same author

Clinical validation of an electronic medical record-based asthma registry at a tertiary care center.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Current status of immunomodulatory therapies in adult sepsis patients: where do we stand?

Expert review of anti-infective therapy·2026
Same author

Good's Syndrome Mirrors a Combined Immunodeficiency with Anti-Cytokine Antibodies in the Total Absence of B Cells.

Journal of clinical immunology·2026
Same author

Janus Kinase Inhibitors as a Therapeutic Option for Chronic Spontaneous Urticaria Refractory to Antihistamines and Omalizumab: A Case Series.

Journal of cutaneous medicine and surgery·2026

Related Experiment Video

Updated: May 28, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Common Variable Immune Deficiency and Pregnancy: Improving Outcomes Through Multidisciplinary Care.

Fatemah Alyaqout1,2, Michael Aw3, Eisa Saleh1

  • 1Division of Clinical Immunology and Allergy, McGill University Health Centre, 1650 Cedar Ave, Montreal, QC H3G 1A4, Canada.

Journal of Clinical Medicine
|May 27, 2026
PubMed
Summary

Managing Common Variable Immune Deficiency (CVID) during pregnancy requires a structured approach. Optimized maternal and fetal outcomes are achievable with immunoglobulin replacement therapy and multidisciplinary care.

Keywords:
common variable immune deficiencyimmunoglobulin replacement therapypregnancy

Related Experiment Videos

Last Updated: May 28, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Area of Science:

  • Immunology
  • Obstetrics
  • Reproductive Medicine

Background:

  • Common Variable Immune Deficiency (CVID) poses unique immunological and obstetrical challenges during pregnancy.
  • Limited data from case reports and series exist, highlighting the need for standardized management guidelines.
  • Optimizing maternal and fetal outcomes necessitates a structured approach to care for pregnant individuals with CVID.

Purpose of the Study:

  • To review existing literature on pregnancy outcomes and management strategies for women with CVID.
  • To add clinical data through a retrospective chart review of pregnant women with CVID.
  • To develop a framework for managing CVID pregnancies.

Main Methods:

  • Conducted a narrative literature review with a structured search.
  • Performed a 10-year retrospective chart review of pregnant women with CVID at a single institution.
  • Synthesized findings to inform management strategies and identify knowledge gaps.

Main Results:

  • Pre-conception planning, regular IgG monitoring, and adjusted immunoglobulin replacement therapy (IgRT) improve pregnancy outcomes.
  • Proactive management of complications and multidisciplinary care are crucial.
  • Subcutaneous immunoglobulin may provide better IgG level stability and flexibility.

Conclusions:

  • Many CVID patients can achieve favorable maternal and neonatal outcomes with IgRT and coordinated multidisciplinary care.
  • A stepwise multidisciplinary framework is proposed for managing CVID pregnancies.
  • Further research is needed to address knowledge gaps in CVID pregnancy management.