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Related Experiment Video

Updated: May 28, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Oligometastatic Prostate Cancer: Clues from an N-of-1.

Alexander Kirschenbaum1, Parisa Verma2, Pamela Cheung2

  • 1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Journal of Clinical Medicine
|May 27, 2026
PubMed
Summary

This case study presents a rare instance of oligometastatic prostate cancer (mPCa) successfully treated with surgery, achieving no evidence of active disease 20 years later. It suggests metastases-directed therapy may be a viable primary treatment for select mPCa patients.

Area of Science:

  • Oncology
  • Urology
  • Cancer Metastasis Research

Background:

  • Metastatic prostate cancer (mPCa) often requires systemic therapy with significant side effects.
Keywords:
PAPPSMAcastration-resistancehypoxiaoligometastasesplasticityprostate cancer

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  • Oligometastasis, characterized by limited metastatic deposits, presents a potential target for localized treatment with curative intent.
  • Current treatments for mPCa, like androgen ablation, are rarely curative and cause morbidity.