Related Experiment Video
Updated: May 28, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Bone Pain Is Associated with Short Radiographic Progression-Free Survival in Patients with Metastatic
Aykut Özmen1, Caner Kapar2, İlkay Gültürk3
1Department of Medical Oncology, Başakşehir Çam and Sakura City Hospital, Istanbul 34480, Turkey.
Journal of Clinical Medicine
|May 27, 2026
Summary
Bone pain in metastatic castration-sensitive prostate cancer (mCSPC) patients independently predicts shorter radiographic progression-free survival (rPFS). This finding aids in risk stratification and treatment decisions for mCSPC.
Area of Science:
- Oncology
- Prostate Cancer Research
- Clinical Prognostics
Background:
- Metastatic castration-sensitive prostate cancer (mCSPC) poses significant challenges in predicting patient outcomes.
- Bone pain is a common symptom, but its independent prognostic value in mCSPC is not fully established.
Purpose of the Study:
- To evaluate the prognostic significance of bone pain at presentation in mCSPC.
- To assess the association between bone pain and radiographic progression-free survival (rPFS), independent of known prognostic factors.
Main Methods:
- Retrospective analysis of 205 mCSPC patients.
- Kaplan-Meier method for rPFS estimation and log-rank test for comparisons.
- Chi-squared and Wilcoxon tests for baseline characteristic comparisons based on bone pain status.
Main Results:
- Median rPFS was 23.8 months overall.
- Patients with bone pain had significantly shorter rPFS (16.9 months) versus those without (29.5 months) (p < 0.001).
- Bone pain, low albumin, low hemoglobin, and liver metastasis were independent predictors of shorter rPFS in multivariate analysis.
Conclusions:
- Bone pain at presentation is a significant independent prognostic factor for reduced rPFS in mCSPC.
- Identifying bone pain can improve risk stratification and inform treatment strategies for mCSPC patients.
Related Concept Videos
01:29Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...