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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Updated: May 28, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Association Between Sleep Apnea Symptoms Subtypes and Obesity.

Mario Henríquez-Beltrán1,2,3, Daniel Solomons4,5, María F Troncoso6

  • 1Núcleo de Investigación en Ciencias de la Salud, Universidad Adventista de Chile, Chillán 3780000, Chile.

Journal of Clinical Medicine
|May 27, 2026
PubMed
Summary

Obesity is common in obstructive sleep apnea (OSA) and linked to specific symptom subtypes, especially excessive daytime sleepiness. Understanding these OSA phenotypes can improve patient care.

Keywords:
OSAexcessive daytime sleepinessobesityobstructive sleep apneasleep

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Area of Science:

  • Sleep Medicine
  • Internal Medicine
  • Public Health

Background:

  • Obstructive sleep apnea (OSA) is a widespread and complex condition.
  • Obesity frequently co-occurs with OSA, but its impact on specific OSA symptom presentations is not well understood.

Purpose of the Study:

  • To investigate the association between obesity and distinct obstructive sleep apnea symptom subtypes within a clinical population.
  • To identify how obesity influences the clinical phenotypes of OSA patients.

Main Methods:

  • Analysis of data from the prospective Santiago Obstructive Sleep Apnea (SantOSA) cohort.
  • Latent class analysis to define OSA symptom subtypes.
  • Multivariable regression models to assess the relationship between obesity and symptom subtypes, adjusting for key covariates.

Main Results:

  • Three OSA symptom subtypes were identified: non-sleepy, disturbed sleep, and excessive daytime sleepiness.
  • Obesity was prevalent in 50.2% of patients and independently associated with the excessive daytime sleepiness subtype.
  • Obese OSA patients exhibited higher rates of severe OSA, hypertension, and diabetes compared to non-obese patients.

Conclusions:

  • Obesity is a significant factor in OSA, correlating with specific symptom profiles like excessive daytime sleepiness and disturbed sleep.
  • Recognizing OSA symptom subtypes alongside obesity status is crucial for comprehensive disease management and personalized treatment strategies.