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Updated: May 28, 2026
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Allergic Status, Long COVID, and Post-Restriction Respiratory Outcomes in Children: A Single-Center
Giulia Brindisi1, Alessandra Gori1, Elia Pignataro1
1Department of Maternal, Infantile and Urological Sciences, La Sapienza University of Rome, 00161 Rome, Italy.
Journal of Clinical Medicine
|May 27, 2026
Summary
Children with allergies face higher odds of Long COVID after SARS-CoV-2 infection, though allergies don't increase infection risk. Vaccination reduces infection rates, and allergic respiratory symptoms worsened post-restrictions.
Area of Science:
- Pediatric Allergy and Immunology
- Infectious Diseases
- Respiratory Medicine
Background:
- The interplay between allergic conditions, SARS-CoV-2 infection, Long COVID, and respiratory health in children is not fully understood.
- Existing research has not comprehensively evaluated the impact of allergic status and vaccination on post-restriction respiratory outcomes.
Purpose of the Study:
- To investigate the association between allergic status and Long COVID in children with confirmed SARS-CoV-2 infection.
- To examine the relationship between SARS-CoV-2 vaccination and changes in allergic rhinitis, asthma, and upper respiratory infections following COVID-19 restrictions.
Main Methods:
- A single-center, questionnaire-based observational study was conducted in a pediatric tertiary-care cohort (0-16 years).
- Parents completed email surveys on SARS-CoV-2 infection, vaccination, persistent symptoms, allergies, and respiratory infections.
- Statistical analyses, including adjusted odds ratios, were used to assess associations.
Main Results:
- Allergic status was linked to increased odds of Long COVID (aOR 3.12) among infected children, but not to a higher risk of SARS-CoV-2 infection.
- Complete vaccination correlated with reduced SARS-CoV-2 infection risk (aOR 0.20) but showed no independent association with Long COVID.
- Post-restriction, 90.1% of allergic children reported worsening allergic rhinitis and 52.0% worsening asthma.
Conclusions:
- Pediatric allergic status is associated with a higher likelihood of Long COVID following SARS-CoV-2 infection, independent of infection risk.
- While vaccination lowers infection risk, it does not appear to independently influence Long COVID development in this cohort.
- Worsening allergic respiratory symptoms were common after restrictions, irrespective of infection history or allergic status.
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