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Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer
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Pyroptosis-Related Gene Signatures and Immune Modulation in Ovarian Cancer: Insights from Multi-Omics and Machine

Rakesh Arya1, Viplov Kumar Biswas2, Hemlata Shakya3

  • 1Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea.

Genes
|May 27, 2026
PubMed
Summary

Pyroptosis-related genes are crucial in ovarian cancer (OVCA) development. CEP55, a key pyroptosis gene, shows potential as a biomarker for early detection and therapy in OVCA.

Keywords:
CEP55biomarkerimmune infiltrationmachine learningovarian cancerpyroptosisscRNA-seq

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Published on: January 12, 2020

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Ovarian cancer (OVCA) is a leading cause of gynecologic cancer mortality, often diagnosed late.
  • Pyroptosis, a programmed cell death pathway, influences tumor progression and immune responses.
  • Identifying pyroptosis-related genes is key to understanding OVCA and finding new biomarkers.

Purpose of the Study:

  • To systematically profile pyroptosis-related genes in OVCA.
  • To identify robust pyroptosis-related gene biomarkers for OVCA diagnosis and prognosis.
  • To explore the role of pyroptosis in OVCA pathogenesis and immune regulation.

Main Methods:

  • Analysis of microarray data (GSE54388) for pyroptosis-related gene expression.
  • Assessment of immune cell infiltration and pathway enrichment (GSEA).
  • Identification of hub genes using Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning for biomarker discovery.
  • Validation using independent datasets (bulk and scRNA-seq) and survival analysis (KMplot).

Main Results:

  • OVCA samples exhibited reduced infiltration of key immune cells (T cells, monocytes, dendritic cells).
  • Pyroptosis-related genes were linked to cell cycle regulation and mitotic progression.
  • CEP55 was identified as a core biomarker with high diagnostic accuracy (AUC 0.972) and was upregulated in OVCA.
  • CEP55 expression correlated with altered immune cell populations and predicted poorer overall and progression-free survival.

Conclusions:

  • Pyroptosis-related genes significantly contribute to OVCA pathogenesis.
  • CEP55 is a promising biomarker for early OVCA detection and a potential therapeutic target.
  • CEP55 links cell cycle regulation with immune modulation in ovarian cancer.