Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Disorders of the Female Reproductive System

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Comprehensive Review of Antimicrobial Peptides and Smart Biomaterials in Chronic Wound Therapy: Overcoming Biofilms, Resistance, and Translational Barriers.

International journal of molecular sciences·2026

Same author

Footwear Heel Height and Gait Biomechanics in Healthy Young Women: A Within-Subject Analysis of Spatiotemporal Parameters, Propulsion, and Pelvic Kinematics.

Life (Basel, Switzerland)·2026

Same author

Neonatal Hypoglycemia: A Systematic Review of International and Local Clinical Guidelines with Clinical Implications.

Journal of clinical medicine·2026

Same author

Developmental Versus Chromosomal Competence in Endometriosis: A Stepwise IVF Outcome Analysis.

Medicina (Kaunas, Lithuania)·2026

Same author

Multi-Kingdom Synergy of <i>Perilla frutescens</i>-Derived Effector Vesicles and Postbiotics: A Triple-Action Strategy for Atopic Dermatitis.

Life (Basel, Switzerland)·2026

Same author

Discordance Between Conventional Ultrasound and Transient Elastography in Hepatic Steatosis Assessment: Clinical Factors Associated with Discrepant Findings.

Diagnostics (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: May 28, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Endometriosis Uncovered: From Chronic Inflammation to Reproductive Dysfunction and Impaired ART Outcomes.

Luana Ghilea Seleș¹, Viorela Romina Murvai², Laura Maghiar³

¹Doctoral School of Biological and Biomedical Sciences, University of Oradea, 1 University Street, 410087 Oradea, Romania.

Medicina (Kaunas, Lithuania)

|May 27, 2026

Summary

Endometriosis is a systemic inflammatory and immune disorder impacting fertility. Chronic inflammation and immune dysregulation negatively affect reproductive health and assisted reproductive technology (ART) outcomes.

Keywords:

assisted reproductive technology biomarkers cytokines endometriosis immune dysregulation infertility inflammation

More Related Videos

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Related Experiment Videos

Last Updated: May 28, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Area of Science:

Reproductive Immunology
Gynecological Disorders
Inflammatory Diseases

Background:

Endometriosis affects 6-10% of reproductive-aged women, often linked to infertility.
It is increasingly recognized as a systemic inflammatory and immune-mediated disease, not just a localized condition.
Chronic inflammation and immune dysregulation are implicated in disease progression and impaired reproductive function.

Purpose of the Study:

To review current evidence on inflammatory and immunological mechanisms in endometriosis.
To evaluate the impact of these mechanisms on reproductive dysfunction.
To assess their influence on assisted reproductive technology (ART) outcomes.

Main Methods:

Comprehensive narrative review of PubMed, Scopus, and Web of Science databases.
Selection of articles from the last decade using keywords: endometriosis, inflammation, immune response, cytokines, ART outcomes.
Inclusion of clinical and experimental studies examining inflammatory markers, immune alterations, and reproductive performance.

Main Results:

Endometriosis is linked to elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and oxidative stress.
Immune dysfunction includes activated macrophages, reduced NK cell activity, and T-cell imbalances.
These alterations negatively impact oocyte quality, fertilization, embryo development, and endometrial receptivity.

Conclusions:

Endometriosis is a systemic immuno-inflammatory disorder significantly affecting reproductive health.
Chronic inflammation and immune dysregulation are central to endometriosis-related infertility and suboptimal ART outcomes.
Further research is needed for reliable biomarkers and targeted therapies to enhance reproductive success.