Noninvasive NESA Microcurrent Neuromodulation for Refractory Overactive Bladder in Women: A Triple-Blind, Randomized,...

Area of Science:

• Neurology
• Urology
• Medical Devices

Background:

• Overactive bladder (OAB) significantly impacts quality of life and sleep, especially in women with refractory symptoms.
• Non-invasive neuromodulation offers a potential therapeutic avenue by targeting autonomic regulation.
• NESA (non-electrical stimulation for autonomic regulation) is an emerging non-invasive neuromodulation technique.

Purpose of the Study:

• To evaluate the efficacy and safety of NESA neuromodulation for treating overactive bladder (OAB) in women.
• To assess the impact of NESA on urinary frequency, quality of life, and sleep disturbances.

Main Methods:

• A triple-blind, randomized, sham-controlled pilot trial was conducted.
• Participants included women aged 18+ with refractory OAB, randomized to active NESA or sham treatment.
• The study involved 10 sessions of NESA or sham, with outcomes assessed via voiding diaries and validated questionnaires.

Main Results:

• NESA treatment led to a significant reduction in mean daily micturitions compared to sham (p=0.043).
• Significant improvements in sleep quality (PSQI, p=0.001) and insomnia severity (ISI, p=0.001) were observed with NESA.
• No device-related adverse events were reported, indicating a favorable safety profile.

Conclusions:

• NESA neuromodulation demonstrated preliminary efficacy and safety in treating refractory overactive bladder (OAB).
• The primary benefits were observed in reducing urinary frequency and improving sleep outcomes.
• Larger, powered trials are necessary to validate these findings and guide clinical application.