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Preoperative Systemic Inflammatory Marker Profile in Surgically Treated Intradural Spinal Tumors: A Retrospective
Muhammet Kırkgeçit1, Hasan Türkoğlu2, Muharrem Furkan Yüzbaşı3
1Department of Neurosurgery, Megapoint Hospital, Kahramanmaraş 46100, Turkey.
Medicina (Kaunas, Lithuania)
|May 27, 2026
Summary
Patients with intradural spinal tumors show elevated preoperative systemic inflammatory markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) compared to controls. These changes are independent of tumor type or motor deficit.
Area of Science:
- Oncology
- Immunology
- Neurosurgery
Background:
- Systemic inflammatory markers from complete blood counts may indicate underlying disease processes.
- Intradural spinal tumors represent a significant clinical challenge, necessitating better understanding of host responses.
Purpose of the Study:
- To investigate preoperative differences in systemic inflammatory markers between patients with intradural spinal tumors and healthy controls.
- To determine if these inflammatory marker differences vary by tumor pathology or motor deficit severity.
Main Methods:
- Complete blood counts were analyzed for 64 patients with intradural spinal tumors and 64 matched controls.
- Calculated markers included NLR, PLR, LMR, SII, PIV, and RDW.
- Comparisons were stratified by pathological subtype and motor deficit status.
Main Results:
- Elevated NLR, PLR, SII, and PIV were observed in the tumor group (p < 0.001).
- Lower LMR was found in the tumor group (p < 0.001).
- No significant differences in markers were found across pathological subtypes or motor deficit levels.
Conclusions:
- Intradural spinal tumors are associated with a preoperative systemic inflammatory response.
- This inflammatory shift appears to be a generalized host response, not specific to tumor histology or neurological presentation.
- The clinical utility of these markers in decision-making requires further investigation.
