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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Meiosis II01:57

Meiosis II

Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each containing...
Oogenesis02:07

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

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Updated: May 28, 2026

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Developmental Versus Chromosomal Competence in Endometriosis: A Stepwise IVF Outcome Analysis.

Luana Ghilea Seleș1,2, Viorela Romina Murvai3, Patronela Naghi4

  • 1Department of Surgical Sciences, Obstetrics and Gynecology, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.

Medicina (Kaunas, Lithuania)
|May 27, 2026
PubMed
Summary

Endometriosis may affect early embryo development in IVF, but chromosomal competence is preserved. This study analyzed IVF outcomes sequentially, finding no significant differences between endometriosis patients and controls in key embryological parameters.

Keywords:
IVFPGT-Aaneuploidyblastocyst formationembryo competenceendometriosisoocyte maturationreproductive outcomes

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • Gynecology

Background:

  • Endometriosis is a gynecological condition linked to infertility, with its precise impact on embryo competence requiring further elucidation.
  • Understanding embryo competence is crucial for improving in vitro fertilization (IVF) success rates.

Purpose of the Study:

  • To evaluate embryo competence by analyzing IVF outcomes across developmental stages.
  • To compare IVF performance between patients with endometriosis and controls.

Main Methods:

  • Retrospective observational study of 160 IVF patients (55 endometriosis, 105 controls).
  • Sequential analysis of embryological data from oocyte retrieval to euploid blastocyst formation.
  • Calculation of stage-specific efficiency rates and correlation analysis.

Main Results:

  • A progressive decline in IVF developmental efficiency was observed across all stages.
  • Strong correlations exist between early parameters (oocyte retrieval, MII oocytes) and embryo yield.
  • No significant differences in embryological parameters were found between endometriosis and control groups.

Conclusions:

  • IVF outcomes demonstrate a sequential decline in efficiency.
  • Endometriosis may impact early embryo development, but chromosomal competence appears unaffected.
  • Sequential analysis offers insights beyond direct group comparisons in IVF studies.