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Updated: May 28, 2026
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Mouse Adipose Tissue Collection and Processing for RNA Analysis
Published on: January 31, 2018
Circulating Long Non-Coding RNAs as a Promising Non-Invasive Tool to Trace Adiposity Capacity Following Obesity
Kazim Senol1, Secil Ak Aksoy2, Gulcin Tezcan3
1Department of General Surgery, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey.
Life (Basel, Switzerland)
|May 27, 2026
Summary
Plasma levels of NEAT1 and HULC long non-coding RNAs (lncRNAs) decrease after sleeve gastrectomy, correlating with weight loss and metabolic improvements in obese patients.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- Long non-coding RNAs (lncRNAs) like NEAT1, HULC, and MALAT1 are involved in adiposity.
- Plasma expression changes of these lncRNAs after rapid weight loss via sleeve gastrectomy are not well understood.
Purpose of the Study:
- To investigate the relationship between plasma NEAT1, HULC, and MALAT1 expression and short-term weight loss post-sleeve gastrectomy.
Main Methods:
- Plasma samples were collected from patients before and 30 days after sleeve gastrectomy.
- Expression levels of NEAT1, HULC, and MALAT1 were measured using RNA extraction.
- Changes in BMI and HbA1C were monitored over 12 months, with associations analyzed.
Main Results:
- Obese patients had higher pre-surgery NEAT1 and HULC levels than non-obese individuals.
- Sleeve gastrectomy significantly reduced NEAT1 and HULC expression.
- NEAT1 and HULC levels correlated with changes in HbA1C and BMI, respectively.
Conclusions:
- Plasma NEAT1 and HULC expression are linked to short-term metabolic and anthropometric changes after sleeve gastrectomy.
- Findings are preliminary, requiring larger studies for clinical validation.
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