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The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Updated: May 28, 2026

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
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Published on: July 4, 2018

Oral Health and Gut-Targeted Microbial Marker Changes Associated with Prolonged Hospitalization in Cardiac Patients:

Ionica Grigore1, Delia Hînganu2, Marius Valeriu Hînganu2

  • 1Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galați, 800008 Galați, Romania.

Life (Basel, Switzerland)
|May 27, 2026
PubMed
Summary

Early oral health changes and gut microbial markers may help predict prolonged hospitalization in cardiac patients. Multidomain monitoring can identify at-risk individuals, improving patient outcomes and resource management.

Keywords:
cardiac patientsgut microbiomeoral healthprolonged hospitalization

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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

Published on: December 31, 2017

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Published on: December 31, 2017

Area of Science:

  • Cardiology
  • Microbiology
  • Oral Health

Background:

  • Prolonged hospitalization in cardiac patients increases morbidity and healthcare costs.
  • Early biological predictors for extended hospital stays are not well-defined.

Purpose of the Study:

  • To investigate oral health and gut microbial markers for identifying cardiac patients at risk of prolonged hospitalization.
  • To explore an integrative framework combining these factors with clinical variables.

Main Methods:

  • Comparative observational study of short-term (1-4 days) versus prolonged (≥25 days) hospitalized cardiac patients.
  • Longitudinal assessment of oral health and targeted gut bacterial markers (qRT-PCR).
  • Multivariate logistic regression analysis adjusted for clinical factors.

Main Results:

  • Prolonged hospitalization patients showed progressive oral health decline (16% impairment by week 2) and modest gut microbial shifts.
  • Short-term patients had stable oral health and microbial profiles.
  • Integrative models indicated potential complementary information from oral health and microbial markers.

Conclusions:

  • Oral health status and gut microbial composition are relevant early indicators in cardiac patients.
  • Multidomain monitoring may aid in early identification of patients at risk for prolonged hospitalization.
  • Further research with larger sample sizes is warranted.