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Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
08:50

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Infectious Complications in Metabolic and Bariatric Surgery: A Comprehensive Narrative Review of Pathophysiology,

Marcello Agosta1,2, Egle Augello3, Carlo Maria Bellanca4,5

  • 1Department of General Surgery, Cannizzaro Hospital, via Messina 829, 95126 Catania, Italy.

Life (Basel, Switzerland)
|May 27, 2026
PubMed
Abstract

Insights

Infectious complications after metabolic and bariatric surgery are influenced by patient factors, microbes, and surgical methods. A structured approach to prevention and management is key to improving outcomes for these severe obesity treatments.

Area of Science:

  • Surgery
  • Infectious Diseases
  • Obesity Medicine

Background:

  • Metabolic and bariatric surgery treats severe obesity and related conditions.
  • Infectious complications are significant despite advances, leading to readmission and mortality.

Purpose of the Study:

  • To review infectious complications following metabolic and bariatric surgery.
  • To synthesize evidence on prevention and management strategies.

Main Methods:

  • Narrative literature review.
  • Synthesis of evidence across five domains: host pathophysiology, microbial epidemiology, preoperative optimization, antimicrobial prophylaxis, and diagnosis/management.

Main Results:

  • Obesity presents unique infection risks (inflammation, immune dysfunction, hypoxia).
  • Prevention involves multidisciplinary optimization, antisepsis, weight-based prophylaxis, and enhanced recovery.
  • Anastomotic leaks and abscesses are severe, requiring prompt recognition and coordinated care.

Conclusions:

  • Infectious complications arise from host, microbial, pharmacological, and surgical interactions.
  • A structured approach to prevention, diagnosis, and management improves outcomes.
  • More bariatric-specific research is needed to support preventive and therapeutic strategies.
Keywords:
anastomotic leakantibiotic prophylaxisbariatric surgerymeta-inflammationmetabolic surgeryobesitypostoperative managementsurgical site infection

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