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Published on: July 31, 2019

Fermentation of Premna microphylla Turcz. by Eurotium cristatum Enhanced Its Nutrients and Antidiabetic Activity

Zhengwei Tan1, Xiangnan Zhang1, Ruzhi Yang2

  • 1Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.

Foods (Basel, Switzerland)
|May 27, 2026
PubMed

Insights

Probiotic fermentation of Premna microphylla Turcz. with Eurotium cristatum (EFPT) improved its nutritional profile. EFPT demonstrated significant antidiabetic effects in a type 2 diabetes mellitus mouse model, outperforming the unfermented powder.

Area of Science:

  • Nutritional science and microbiology
  • Pharmacology and toxicology

Background:

  • Type 2 diabetes mellitus (TIIDM) poses a significant global health challenge.
  • Premna microphylla Turcz. is a traditional herb with potential health benefits.
  • Probiotic fermentation can enhance the bioavailability and bioactivity of plant-derived compounds.

Purpose of the Study:

  • To develop and characterize a probiotic fermented Premna microphylla Turcz. product (EFPT).
  • To evaluate the antidiabetic efficacy of EFPT in a TIIDM mouse model.
  • To investigate the impact of fermentation on the nutritional composition and bioactive compounds of Premna microphylla Turcz.

Main Methods:

  • Development of EFPT using Eurotium cristatum fermentation.
  • Analysis of nutritional components including pectin, polysaccharides, polyphenols, soluble proteins, SCFAs, monosaccharides, and amino acids.
  • Induction of TIIDM in mice using a high-fat diet and streptozotocin.
  • Administration of EFPT and non-fermented powder to assess antidiabetic effects and organ damage.

Main Results:

  • Fermentation significantly increased pectin and water-soluble polysaccharides while decreasing polyphenols and soluble proteins.
  • Alterations in SCFAs, monosaccharides, and amino acid profiles were observed post-fermentation.
  • EFPT exhibited dose-dependent antidiabetic activity, superior to the unfermented powder, in TIIDM mice.
  • EFPT ameliorated liver and kidney damage, linked to enhanced SCFAs production.

Conclusions:

  • Eurotium cristatum fermentation enhances the nutritional quality and bioactive properties of Premna microphylla Turcz.
  • EFPT possesses potent antidiabetic effects, making it a promising functional food ingredient.
  • The study highlights the potential of fermented herbal products for managing type 2 diabetes mellitus.
Keywords:
Eurotium cristatumPremna microphylla Turcz.fermentationshort-chain fatty acidstype 2 diabetes

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