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Temperature/pH Dual-Responsive Hydrogels: Research Progress in Preparation Methods, Structural Design Strategies and

Sisi Wang¹, Gang Wang^1,2, Xuefei Liu^1,2

¹School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550025, China.

Gels (Basel, Switzerland)

|May 27, 2026

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This summary is machine-generated.

Temperature/pH dual-responsive hydrogels are smart materials with reversible changes. This review details their preparation, design, and biomedical uses in drug delivery, tissue engineering, and diagnostics.

Area of Science:

Materials Science
Biomedical Engineering
Polymer Chemistry

Background:

Smart hydrogels respond to environmental stimuli.
Temperature/pH dual-responsive hydrogels offer advanced functionalities.
These materials are crucial for biomedical applications.

Purpose of the Study:

To systematically review preparation methods, structural designs, and biomedical applications of temperature/pH dual-responsive hydrogels.
To provide a comprehensive overview of recent advancements in the field.
To identify challenges and future research directions.

Main Methods:

Chemical, physical, and hybrid crosslinking for hydrogel preparation.
Fabrication of microsphere, core-shell, and layered structures.

Keywords:

biomedical applications preparation methods smart hydrogels structural design strategies temperature/pH dual-responsive

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Review of literature on hydrogel synthesis and applications.

Main Results:

Detailed comparison of different preparation techniques.
Elucidation of various structural design strategies and fabrication processes.
Summary of progress in drug delivery, cancer therapy, biosensing, tissue engineering, and wound healing.

Conclusions:

Temperature/pH dual-responsive hydrogels show significant promise in diverse biomedical fields.
Further research is needed to address current challenges and unlock future potential.
This review consolidates knowledge for researchers in smart materials and biomedical applications.